Tailoring Treatment for Patients With HR+/HER2- Metastatic Breast Cancer: Examining the Role of Current and Emerging Endocrine Therapies
Podcast 3 (Hurvitz): Biomarkers for endocrine therapies: What do they mean for clinical practice?
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Which of the following is a limitation of using ctDNA assays for cancer detection or monitoring?
Which of the following is a limitation of using ctDNA assays for cancer detection or monitoring?
No mutation data
Reliability at low ctDNA tumor fractions
Lack of standardized definitions
May not track with specific types of cancer
A 56-year-old woman with HR+/HER2- breast cancer experiences disease progression during adjuvant
endocrine therapy. She has no significant comorbidities. Circulating tumor DNA testing identifies a
PIK3CA
mutation. What is the most appropriate treatment option for this patient?
A 56-year-old woman with HR+/HER2- breast cancer experiences disease progression during adjuvant endocrine therapy. She has no significant comorbidities. Circulating tumor DNA testing identifies a PIK3CA mutation. What is the most appropriate treatment option for this patient?
Endocrine therapy (ET) + Everolimus
Endocrine therapy (ET) + trastuzumab + neratinib
Fulvestrant + palbociclib + inavolisib
Chemotherapy
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