Using Multidisciplinary Management to Address Pathophysiologic Pathways in
Paroxysmal Nocturnal Hemoglobinuria
Podcast 3
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A 32-year-old woman with a history of dark urine, abdominal pain, headache, and dyspnea is
diagnosed with PNH. Flow cytometry reveals a large PNH clone affecting red and white blood
cells. Which of the following would be the most appropriate treatment?
B12 supplementation
Folate supplementation
Ravulizumab to inhibit complement-mediated hemolysis
Plasmapheresis to remove PNH red blood cells
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