Strategies to Overcome Endocrine Therapy Resistance in HR+/HER2-negative Breast Cancer
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Which of the following interventions is NOT part of a plan to support a patient’s consistent, chronic, and tolerable use of oral anti-cancer medications for HR-positive/ HER2-negative breast cancer?

Educating the patient on the medications, including how to take them, potential side effects, and how to manage them.

Developing a medication schedule with the patient that is convenient for them and fits into their daily routine.

Monitoring the patient for side effects and adjusting the medication regimen as needed.

Prescribing a different type of medication for the patient if they experience intolerable side effects.

A 52-year-old woman with HR-positive/HER2-negative early breast cancer is starting abemaciclib as part of an adjuvant therapy regimen. Which of the following adverse events is most commonly associated with abemaciclib?

Diarrhea

Neutropenia

Fatigue

Hepatotoxicity

Mrs. Smith is a 55-year-old patient with HR-positive/HER2-negative early breast cancer who is considering taking an oral anti-cancer medication. She is concerned about the potential side effects of the medication but also eager to do everything she can to reduce her risk of recurrence. Which of the following is the BEST shared decision-making strategy that the healthcare provider could use to support her adherence and persistence with the oral anti-cancer medication?

Present her with all available treatment options and their associated risks and benefits, and then ask her to choose the option she is most comfortable with.

Recommend the oral anti-cancer medication based on her medical history and the healthcare provider’s clinical expertise.

Ask her what she hopes to achieve with treatment, and then develop a treatment plan that aligns with her goals and preferences.

Tell her that the oral anti-cancer medication is the best treatment option for her and that she should take the medication regardless of her concerns.

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