Evolving Evidence in the Management of Patients with Non-Small Cell Lung Cancer:
Clinical Pearls for the Community Practitioner
Pre-test
Questions marked with a
*
are required
100%
Contact Information
First Name
Last Name
Email Address
Which statement regarding the findings of the phase 3 clinical trial, EMPOWER-Lung 1, investigating the role
of cemiplimab vs chemotherapy in patients with stage IV NSCLC without actionable driver mutations and PD-
L1 expression ≥50%, is true regarding patients who received cemiplimab?
Both mOS and mPFS were significantly improved
Both mOS and mPFS were improved, but not significantly
Both mOS and mPFS were improved, but only improvements in OS were significant
Both mOS and mPFS were improved, but only improvements in PFS were significant
Alfred is a 67-year-old man who has been diagnosed with advanced NSCLC with no actionable mutations and
a PD-L1 TPS score of 90%. You determine that he is a good candidate for immune checkpoint inhibitor
therapy. Based on current practice guidelines, which of the following regimens would be most appropriate in
the first-line setting for this patient?
Nivolumab/ipilimumab
Nivolumab
Cemiplimab
Cemiplimab + platinum + pemetrexed
Joyce is a 72-year-old woman who has been diagnosed with advanced NSCLC with no actionable mutations
and a PD-L1 TPS score of 80%. You determine that she may be a good candidate for single-agent PD-1/PD-L1
inhibitor therapy, using either atezolizumab, cemiplimab or pembrolizumab. She mentions her friend with
NSCLC who was prescribed dual PD-1/PD-L1 inhibitor therapy and would prefer this more aggressive regimen
to “nip this problem in the bud.” How would you counsel this patient?
Explain that the onset of higher toxicity irAEs is later with the use of dual vs single ICIs
Explain that the onset of all irAEs is similar between dual vs single ICIs
Explain that the incidence of higher toxicity irAEs is more common with the use of dual vs single ICIs
Explain that the incidence of all irAEs is comparable between dual vs single ICIs
Tony is a 66-year-old man who has been diagnosed with advanced NSCLC and a PD-L1 TPS score of 40%. You
recommend combination therapy comprised of platinum doublet chemotherapy and immunotherapy. Tony
responds, saying “Do I have to take chemotherapy? It terrifies me.” Which of the following would be the best
response to Tony’s concerns?
“Let me refer you to a therapist to talk about your worries.”
“Unfortunately, this medication regimen will confer the best survival benefit.”
“Tell me more about what you’ve heard about chemotherapy.”
“The outcome of not taking chemotherapy is scarier.”
Done
Powered by
QuestionPro
Loading...
close
drag_indicator
close
Yes
Cancel
Continue
Answer Question
Continue Without Answering
Keep Data
Discard
close
drag_indicator
Custom Title
highlight_off