The DETECT Initiative in Early Alzheimer’s Disease: Optimizing Collaboration and Multidisciplinary Care to Facilitate Timely Diagnosis
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Jack is a 72-year-old freelance writer who presents to you, his primary care physician, with complaints of forgetting words when he’s writing, missing meetings, and continually losing things like keys and his shoes. He has hyperlipidemia controlled with a statin, had a knee replacement 4 years earlier, walks 2 miles a day, and lives alone. A full medical workup, including a cognitive laboratory panel, yields no concerns. You give him the Mini-Mental State Examination and he scores 22. What is the likely diagnosis? 
Which is the most appropriate test to order at this stage to identify biomarkers of cognitive decline? 
The test results show early signs of Alzheimer’s disease. As part of comprehensive management, you consider all of the following EXCEPT: 
The neurologist confirms the diagnosis. She recommends Jack start on the recently approved drug, lecanemab. She tells Jack that the studies found that:
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