From Awareness to Action: Driving Multidisciplinary Application of Screen and Disease Modifying Therapies in Early Stage T1D
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Which of the following first-degree relatives with a history of type 1 diabetes (T1D) confers the highest
risk for an individual developing the disease?
Mother
Father
Non-identical twin/sibling
Identical twin
A 14-year-old, overweight male patient previously diagnosed with prediabetes has tested positive for the zinc
transporter 8 (ZnT8) and islet antigen-2 autoantibodies (IA-2) after two screenings for T1D. His fasting blood
glucose level is 100 mg/dL. Which is the next best step in the management of this patient?
Diagnose T1D and obtain an OGTT to stage; provide counseling on T1D and achieving a healthy lifestyle
Diagnose T2D due to his weight and blood glucose level, recommend weight-reduction and metformin
Confirm prediabetic status and recommend weight-reducing plan; rescreen for T1D in 6 months
None of the above
In a 14-year-old patient with confirmed dysglycemia based on an OGTT showing a fasting glucose of 100
mg/dL, a 1-hour glucose: 169 mg/dL, and a 2-hour glucose of 114 mg/dL, which of the following is the most
appropriate treatment to consider?
Insulin
Metformin
Teplizumab
Semaglutide
A 12-year-old girl tests positive for one persistent autoantibody at a follow-up visit. Her older sister has
Hashimoto’s disease, and her mother has T2D. Her blood glucose is normal (fasting blood glucose: 87 mg/dL),
and she reports no other symptoms. What do you recommend next?
Rescreen in 3 years
Rescreen in 12 months
Recommend continuous glucose monitoring for the next 6 months
Prescribe teplizumab
The previous patient has tested positive for two persistent autoantibodies 5 years later at 17 years of age
after being lost to follow up. Her 2-hour blood glucose is 265 mg/dL. She reports being thirsty often and has
unintentionally lost about 5 pounds in the past 1.5 months. What do you recommend next?
Insulin
Metformin
Teplizumab
Semaglutide
Done
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