Clinical Pearls for Oncologists and Neurologists: Comprehensive Care for Patients with Neurofibromatosis Type 1 Across the Lifespan
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Jill, a 29-year-old with a history of café au lait spots and axillary freckling and a slowly growing mass on her upper back presents to your clinic for progressive symptoms. Which of the following features is most commonly seen with symptomatic PNs in adults with NF1?
Wendy, a 5-year old with NF1, has progressive PN with pain and major deformity. You are considering starting her on mirdametinib oral suspension. According to the ReNeu study, all of the following outcomes observed with mirdametinib in NF1-PN patients are accurate EXCEPT 
Holly, a 6-year-old patient on selumetinib for NF1-PN develops grade 3 acneiform rash and diarrhea. What would be the next best steps based on current clinical practice recommendations?
An 18-year-old patient with NF1-PN presents with a growing orbital PN, hypertension, and increased facial disfigurement. In addition to being very anxious about her looks, she is also concerned about malignant transformation of the PN. Which care plan is most beneficial for optimizing long-term outcomes in this patient?
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