A Community Approach to CAR-T Therapy for Patients with DLBCL or FL: Optimizing Referral, Coordination, and Care
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Which of the following is a patient-related barrier for treatment with chimeric antigen receptor (CAR) T-cell
therapy?
Which of the following is a patient-related barrier for treatment with chimeric antigen receptor (CAR) T-cell therapy?
Late referral to a tertiary treatment center for CAR T-cell therapy assessment
Lack of understanding of appropriate adverse event monitoring and management by referring physicians
Lack of adequate caregiver support or ability to travel
Ineffective communication between community practice and academic centers
Which of the following patients with relapsed or refractory B-cell lymphoma would NOT be considered an
appropriate candidate for referral to a CAR T-cell therapy center?
Which of the following patients with relapsed or refractory B-cell lymphoma would NOT be considered an appropriate candidate for referral to a CAR T-cell therapy center?
A patient with diffuse large B-cell lymphoma (DLBCL) and early relapse (within 12 months) after R- CHOP (or Pola-R-CHP)
A patient with DLBCL after relapse on front-line chemoimmunotherapy and not eligible for hematopoietic stem cell transplantation due to comorbidities or age
A patient with follicular lymphoma about to be initiated on second-line therapy after developing progressive disease five years after front line BR
A patient with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy
Susan is a 74-year-old female with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). She was initially
treated with front-line polatuzumab vedotin + R-CHP. Now eight months later, her disease is progressing. Susan has an
ECOG performance status (PS) of 1. Which of the following treatment approaches would be most appropriate
for Susan?
Susan is a 74-year-old female with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). She was initially treated with front-line polatuzumab vedotin + R-CHP. Now eight months later, her disease is progressing. Susan has an ECOG performance status (PS) of 1. Which of the following treatment approaches would be most appropriate for Susan?
CAR T-cell therapy
Single agent rituximab
Loncastuximab tesirine
Bispecific antibody with gemcitabine/oxaliplatin
Brent is a 67-year-old man who has been referred for CAR-T therapy after receiving two prior lines of
treatment for follicular lymphoma (FL). Currently, his disease has transformed to an aggressive large B-cell
lymphoma subtype (CD19+, CD20-, BCL6+; Ki-67 72%) and he is experiencing explosive disease progression.
What is the most appropriate course for Brent’s treatment at this time?
Brent is a 67-year-old man who has been referred for CAR-T therapy after receiving two prior lines of treatment for follicular lymphoma (FL). Currently, his disease has transformed to an aggressive large B-cell lymphoma subtype (CD19+, CD20-, BCL6+; Ki-67 72%) and he is experiencing explosive disease progression. What is the most appropriate course for Brent’s treatment at this time?
Defer CAR T-cell therapy due to rapid disease progression, as he is no longer a candidate
Treatment with an anti CD20 x CD3 bispecific antibody
Leukapheresis followed by bridging therapy while awaiting CAR T-cell manufacturing
Initiate R-GemOx chemotherapy
Refer for radiation therapy to control bulky disease
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