Checkpoint Inhibition Combinations in Melanoma: Evaluating Current Therapies and the Role of Anti-LAG3 Antibodies
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Each of the following represents LAG-3 inhibitors that are used in dual immune checkpoint blockade to treat metastatic melanoma, EXCEPT:
Fianlimab
Nivolumab
Relatlimab
A & C
In the RELATIVITY-047 trial, what percentage of patients discontinued the fixed-dose combination of nivolumab and relatlimab due to adverse events?
7.0%
20.5%
15.2%
33.0%
A 58-year-old man presents with fatigue and hard black nodules on his arm. He has controlled hypertension. He is diagnosed with metastatic melanoma, with an ECOG of 1. Various scans show that the cancer has metastasized to the lung, bone, and lymph nodes. He is
BRAF
V600K mutation negative and he has elevated liver transaminases. His renal function is normal, but serum LDH is 8500 U/L. Which is the following would be the most appropriate first-line therapy for this patient?
Dabrafenib plus trametinib
Ipilimumab
Interleukin-2
Nivolumab plus relatlimab
What is your job role?
Oncologist
Dermatologist
Nurse Practitioner
Oncology Pharmacist
Internist
Physician Assistant
Primary Care Physician
Other
What is your type of practice?
Hospital
Community/Private
SNF/Nursing Home
Academic
HMO/MCO
Other
How many years have you been in practice?
Less than 5
5 to 9
10 to 15
More than 15
N/A
Please estimate the number of patients with melanoma that you provide for weekly:
Fewer than 5
5 to 10
11 to 15
16 to 20
21 to 30
31 to 50
>50
N/A
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