Community Practice Considerations: Emerging Bispecific Antibodies in NHL
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Which of the following is not a CD20/CD3 bispecific antibody in late-phase clinical testing for Non-Hodgkin’s Lymphoma (NHL)?
Epcoritamab
Mosunetuzumab
Tafasitamab
Glofitamab
Which of the following therapies is FDA-approved for the 2nd line treatment of R/R large B-cell lymphoma?
Epcoritamab
Ibrutinib
Pembrolizumab
Lisocabtagene maraleucel
A 66-year-old woman diagnosed with follicular lymphoma transformed into high-grade B-cell lymphoma, treated with DA-EPOCH-R x six cycles, and maintenance rituximab. She then progressed and received axi-cel, which was complicated by grade 4 CRS and grade 2 ICANS. She then progressed again 2 months after axi-cel and received pola-BR. Unfortunately, she developed progressive disease during her second cycle with pola-BR. Which of the following therapies would you recommend next?
Polatuzumab vedotin + R-CHP
Loncastuximab
Mosunetuzumab
Selinexormonotherapy
The most common adverse event in clinical trials evaluating bispecific antibodies was: (LO3)
Neuropathy
Cytokine release syndrome
Neurotoxicity
Neutropenia
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