Updates in the PIK3KCA-Related Overgrowth Spectrum (PROS) Disorders: Updates in Diagnosis, Targeted Therapy, and Treatment
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Which of the following best describes PROS?
The burden of PIK3KCA-Overgrowth Related Spectrum (PROS) is best described by: 
A 3.5y old child is brought for a consult after she was referred by her pediatric geneticist who documented a somatic PIK3CA mutation via NGS testing.  She has difficulty ambulating (macrodactyly of both feet and syndactyly of the left 2nd and 3rd toes) and has large birth marks on the trunk.  The mother is searching for a diagnosis and potential interventions. Potential interventions are?
Parents decide to start alpelisib treatment. What are adverse reactions you should discuss?
Treatment options for PROS: 
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