Community Practice Considerations: Emerging Bispecific Antibodies in NHL
Podcast 1: Introduction to NHL: Epidemiology, Prognostication, and Treatment strategies for relapsed/refractory NHL
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Which of the following is not an FDA approved therapy option for patients with relapsed/refractory DLBCL:
Polatuzumab + bendamustine + rituximab
ASCT + chemotherapy
Axicabtagene ciloleucel
Glofitamab
Which of the following therapies is a bispecific antibody that is currently in clinical trials for the treatment of NHL:
Epcoritamab
Ibrutinib
Pembrolizumab
Lisocabtagene maraleucel
A 55-year-old woman presents with GCB (not DEL) subtype of DLBCL. Her PET-CT shows FDG-avid adenopathy above and below diaphragm and she receives treatment with six cycles of R-CHOP and achieves a CR. She relapses a year later and is treated as part of a clinical trial with second-line axicabtagene ciloleucel, complicated by grade 3 CRS and grade 3 confusion. She is also treated with tocilizumab and dexamethasone, to address related toxicities and her PET-CT 30 days later shows a CR. Unfortunately, she relapses 3 months later with multistation adenopathy and a biopsy confirms a return of DLBCL, with CD19 and CD20 expression. Which of the following options is the most appropriate choice to treat this patient?
Loncastuximab tesirine
Lenalidomide-rituximab
Lisocabtagene maraleucel
Selinexor
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