Clinical Practice Pearls: Managing Patients with Major Depressive Disorder Showing an Inadequate Response to First-Line Therapies

Podcast #2: Recurrent MDD with previous positive response to escitalopram
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What are some of the treatment options available for patients with MDD experiencing inadequate response to first-line therapies?

Augmenting the antidepressant with another therapy

Increasing dosage

Switching to a different antidepressant

Combining antidepressants

All of the above

Rachel is a postmenopausal woman with a history of recurrent MDD and is now experiencing an inadequate response to escitalopram. She has recently had significant weight gain and is very concerned about that as a side effect of medication. What would be your approach regarding her management plan?

Reassess the diagnosis

Evaluate for a comorbid condition

Question adherence to treatment

Counsel the patient to accept potential weight gain associated with treatment