Clinical Practice Pearls: Managing Patients with Major Depressive Disorder Showing an Inadequate Response to First-Line Therapies
Podcast #1: Rapid-onset functional impairment and suicidal ideation upon initial MDD episode
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Angela is 29-year-old woman who is experiencing an inadequate response to SSRI treatment for MDD. What would NOT be the next step in your management approach?
Increase the dosage
Reassess the diagnosis
Evaluate comorbidities (eg, diabetes, OSA, substance use disorder)
Monitor adherence to treatment
Assess patient preferences for next step - switch vs adding a 2nd intervention
In selecting a specific antidepressant for an individual patient, which of the following are true?
Discuss the medication’s pros, cons, and safety issues over other compounds the patient may have already taken
Explain latency of action to provide patients with realistic expectations
Review expected treatment duration
Describe potential side-effects and mechanisms to cope with them
Ensure the patient understands dosage (titration schedule, and compliance recommendations)
Inquire about lifestyle (eg, caffeine and alcohol intake, use of recreational drugs, sleep hygiene, and integration with other concomitant treatments)
All of the above
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