The Implementation of Anti-Amyloid Therapeutics for Alzheimer’s
Disease—Practical Considerations for Pharmacists Regarding Preparation, Access to Care, and Counseling
Pre-test
Questions marked with a
*
are required
100%
Contact Information
First Name
Last Name
Email Address
Which statement best describes the efficacy outcomes seen with lecanemab in the CLARITY-AD trial?
Which statement best describes the efficacy outcomes seen with lecanemab in the CLARITY-AD trial?
It showed no significant reduction in brain amyloid plaques
It demonstrated a 27% slowing of clinical decline on CDR-SB score, with a 59 Centiloid reduction in amyloid PET
It showed improvement only in activities of daily living with no effect on cognitive measures
It demonstrated complete reversal of cognitive decline in early-stage AD patients
When counseling a patient/care partner about starting an anti-amyloid therapy, which monitoring parameter is most critical to discuss?
When counseling a patient/care partner about starting an anti-amyloid therapy, which monitoring parameter is most critical to discuss?
Annual cognitive testing
Monthly complete blood counts
Regular MRI monitoring for amyloid-related imaging abnormalities (ARIA)
Weekly vital sign measurements
Which protocol is correct for donanemab?
Which protocol is correct for donanemab?
Initial dose is 1400 mg for all patients
700 mg every 4 weeks for 3 doses, then 1400 mg every 4 weeks
Fixed dose of 700 mg every 2 weeks
Weight-based dosing of 10 mg/kg every 4 weeks
Which statement about Medicare coverage of anti-amyloid therapies is correct?
Which statement about Medicare coverage of anti-amyloid therapies is correct?
Coverage is automatically approved for all patients over 65
Coverage requires enrollment in a registry and confirmation of amyloid pathology
Coverage is limited to patients who fail conventional AD medications first
Coverage is only available through Medicare Part D
During administration of lecanemab, a 72-year-old patient develops chills, fever and mild nausea 20 minutes into her first infusion. Her blood pressure is 138/82 mmHg and oxygen saturation is 97%. As the infusion pharmacist, what is the most appropriate next step?
During administration of lecanemab, a 72-year-old patient develops chills, fever and mild nausea 20 minutes into her first infusion. Her blood pressure is 138/82 mmHg and oxygen saturation is 97%. As the infusion pharmacist, what is the most appropriate next step?
Immediately discontinue the infusion and administer epinephrine
Continue the infusion at the same rate and observe
Temporarily pause the infusion and assess for response to supportive care measures
Permanently discontinue therapy and refer back to prescriber
Mrs. Rodriguez is 72 with mild cognitive impairment (MCI) due to Alzheimer's disease (confirmed by positive amyloid PET scan). She is being evaluated for anti-amyloid therapy. Brain MRI shows no evidence of cerebral or micro hemorrhages. She takes apixaban 5 mg twice daily for atrial fibrillation. Based on current clinical evidence regarding anti-amyloid therapeutics, which of the following is the most appropriate recommendation?
Mrs. Rodriguez is 72 with mild cognitive impairment (MCI) due to Alzheimer's disease (confirmed by positive amyloid PET scan). She is being evaluated for anti-amyloid therapy. Brain MRI shows no evidence of cerebral or micro hemorrhages. She takes apixaban 5 mg twice daily for atrial fibrillation. Based on current clinical evidence regarding anti-amyloid therapeutics, which of the following is the most appropriate recommendation?
Discontinue apixaban, wait 4 weeks, then initiate lecanemab therapy
Continue apixaban and start lecanemab, but increase brain MRI monitoring frequency
The patient is not a candidate for anti-amyloid therapy due to anticoagulation use
Switch to low-molecular-weight heparin and initiate lecanemab therapy
Done
Powered by
QuestionPro
Loading...
close
drag_indicator
close
Yes
Cancel
Continue
Answer Question
Continue Without Answering
Keep Data
Discard
close
drag_indicator
Custom Title
highlight_off